Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson's disease
Identifieur interne : 002452 ( Main/Corpus ); précédent : 002451; suivant : 002453Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson's disease
Auteurs : Mona K. Beyer ; Kolbjorn S. Bronnick ; Kristy S. Hwang ; Niels Bergsland ; Ole Bjorn Tysnes ; Jan Petter Larsen ; Paul M. Thompson ; Johanne H. Somme ; Liana G. ApostolovaSource :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2013-01.
Abstract
Background and objective Cognitive impairment, including impairment of episodic memory, is frequently found in newly diagnosed Parkinson's disease (PD). In this longitudinal observational study we investigated whether performance in memory encoding, retention, recognition and free recall is associated with reduced hippocampal radial distance. Methods We analysed baseline T1-weighted brain MRI data from 114 PD subjects without cognitive impairment, 29 PD subjects with mild cognitive impairment and 99 normal controls from the ParkWest study. Age- and education-predicted scores for the California Verbal Learning Test 2 (CVLT-2) and tests of executive function were regressed against hippocampal radial distance while adjusting for imaging centre. Results There was no association between encoding or performance on executive tests and hippocampal atrophy in the PD group. In the full PD sample we found bilaterally significant associations between lower delayed free recall scores and hippocampal atrophy in the CA1, CA3 and subiculum area (left, p=0.0013; right, p=0.0082). CVLT-2 short delay free recall scores were associated with bilateral hippocampal CA1 and subicular atrophy in the full PD sample (left, p=0.013; right, p=0.047). CVLT-2 recognition scores showed a significant association with right-sided subicular and CA1 atrophy in the full PD sample (p=0.043). Conclusions At the time of PD diagnosis, subjects’ verbal memory performance in recall and recognition are associated with atrophy of the hippocampus, while encoding is not associated with hippocampal radial distance. We postulate that impaired recall and recognition might reflect deficient memory consolidation at least partly due to structural hippocampal changes.
Url:
DOI: 10.1136/jnnp-2012-303054
Links to Exploration step
ISTEX:0D0083EA1BD08FEC6331BC79186B5DB943BDD70DLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson's disease</title><author><name sortKey="Beyer, Mona K" sort="Beyer, Mona K" uniqKey="Beyer M" first="Mona K" last="Beyer">Mona K. Beyer</name><affiliation><mods:affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Radiology and Nuclear Medicine–Rikshospitalet, Oslo University Hospital, Oslo, Norway</mods:affiliation></affiliation></author><author><name sortKey="Bronnick, Kolbjorn S" sort="Bronnick, Kolbjorn S" uniqKey="Bronnick K" first="Kolbjorn S" last="Bronnick">Kolbjorn S. Bronnick</name><affiliation><mods:affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Hwang, Kristy S" sort="Hwang, Kristy S" uniqKey="Hwang K" first="Kristy S" last="Hwang">Kristy S. Hwang</name><affiliation><mods:affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Bergsland, Niels" sort="Bergsland, Niels" uniqKey="Bergsland N" first="Niels" last="Bergsland">Niels Bergsland</name><affiliation><mods:affiliation>Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Tysnes, Ole Bjorn" sort="Tysnes, Ole Bjorn" uniqKey="Tysnes O" first="Ole Bjorn" last="Tysnes">Ole Bjorn Tysnes</name><affiliation><mods:affiliation>Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</mods:affiliation></affiliation></author><author><name sortKey="Larsen, Jan Petter" sort="Larsen, Jan Petter" uniqKey="Larsen J" first="Jan Petter" last="Larsen">Jan Petter Larsen</name><affiliation><mods:affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M" last="Thompson">Paul M. Thompson</name><affiliation><mods:affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Somme, Johanne H" sort="Somme, Johanne H" uniqKey="Somme J" first="Johanne H" last="Somme">Johanne H. Somme</name><affiliation><mods:affiliation>Department of Neurology, Cruces University Hospital, Baracaldo, Spain</mods:affiliation></affiliation></author><author><name sortKey="Apostolova, Liana G" sort="Apostolova, Liana G" uniqKey="Apostolova L" first="Liana G" last="Apostolova">Liana G. Apostolova</name><affiliation><mods:affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0D0083EA1BD08FEC6331BC79186B5DB943BDD70D</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1136/jnnp-2012-303054</idno><idno type="url">https://api.istex.fr/document/0D0083EA1BD08FEC6331BC79186B5DB943BDD70D/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002452</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson's disease</title><author><name sortKey="Beyer, Mona K" sort="Beyer, Mona K" uniqKey="Beyer M" first="Mona K" last="Beyer">Mona K. Beyer</name><affiliation><mods:affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Radiology and Nuclear Medicine–Rikshospitalet, Oslo University Hospital, Oslo, Norway</mods:affiliation></affiliation></author><author><name sortKey="Bronnick, Kolbjorn S" sort="Bronnick, Kolbjorn S" uniqKey="Bronnick K" first="Kolbjorn S" last="Bronnick">Kolbjorn S. Bronnick</name><affiliation><mods:affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Hwang, Kristy S" sort="Hwang, Kristy S" uniqKey="Hwang K" first="Kristy S" last="Hwang">Kristy S. Hwang</name><affiliation><mods:affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Bergsland, Niels" sort="Bergsland, Niels" uniqKey="Bergsland N" first="Niels" last="Bergsland">Niels Bergsland</name><affiliation><mods:affiliation>Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Tysnes, Ole Bjorn" sort="Tysnes, Ole Bjorn" uniqKey="Tysnes O" first="Ole Bjorn" last="Tysnes">Ole Bjorn Tysnes</name><affiliation><mods:affiliation>Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</mods:affiliation></affiliation></author><author><name sortKey="Larsen, Jan Petter" sort="Larsen, Jan Petter" uniqKey="Larsen J" first="Jan Petter" last="Larsen">Jan Petter Larsen</name><affiliation><mods:affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M" last="Thompson">Paul M. Thompson</name><affiliation><mods:affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Somme, Johanne H" sort="Somme, Johanne H" uniqKey="Somme J" first="Johanne H" last="Somme">Johanne H. Somme</name><affiliation><mods:affiliation>Department of Neurology, Cruces University Hospital, Baracaldo, Spain</mods:affiliation></affiliation></author><author><name sortKey="Apostolova, Liana G" sort="Apostolova, Liana G" uniqKey="Apostolova L" first="Liana G" last="Apostolova">Liana G. Apostolova</name><affiliation><mods:affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-01">2013-01</date><biblScope unit="volume">84</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="23">23</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">0D0083EA1BD08FEC6331BC79186B5DB943BDD70D</idno><idno type="DOI">10.1136/jnnp-2012-303054</idno><idno type="href">jnnp-84-23.pdf</idno><idno type="ArticleID">jnnp-2012-303054</idno><idno type="PMID">23154124</idno><idno type="local">jnnp;84/1/23</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background and objective Cognitive impairment, including impairment of episodic memory, is frequently found in newly diagnosed Parkinson's disease (PD). In this longitudinal observational study we investigated whether performance in memory encoding, retention, recognition and free recall is associated with reduced hippocampal radial distance. Methods We analysed baseline T1-weighted brain MRI data from 114 PD subjects without cognitive impairment, 29 PD subjects with mild cognitive impairment and 99 normal controls from the ParkWest study. Age- and education-predicted scores for the California Verbal Learning Test 2 (CVLT-2) and tests of executive function were regressed against hippocampal radial distance while adjusting for imaging centre. Results There was no association between encoding or performance on executive tests and hippocampal atrophy in the PD group. In the full PD sample we found bilaterally significant associations between lower delayed free recall scores and hippocampal atrophy in the CA1, CA3 and subiculum area (left, p=0.0013; right, p=0.0082). CVLT-2 short delay free recall scores were associated with bilateral hippocampal CA1 and subicular atrophy in the full PD sample (left, p=0.013; right, p=0.047). CVLT-2 recognition scores showed a significant association with right-sided subicular and CA1 atrophy in the full PD sample (p=0.043). Conclusions At the time of PD diagnosis, subjects’ verbal memory performance in recall and recognition are associated with atrophy of the hippocampus, while encoding is not associated with hippocampal radial distance. We postulate that impaired recall and recognition might reflect deficient memory consolidation at least partly due to structural hippocampal changes.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>Mona K Beyer</name><affiliations><json:string>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>Department of Radiology and Nuclear Medicine–Rikshospitalet, Oslo University Hospital, Oslo, Norway</json:string></affiliations></json:item><json:item><name>Kolbjorn S Bronnick</name><affiliations><json:string>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Kristy S Hwang</name><affiliations><json:string>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</json:string><json:string>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</json:string></affiliations></json:item><json:item><name>Niels Bergsland</name><affiliations><json:string>Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, New York, USA</json:string></affiliations></json:item><json:item><name>Ole Bjorn Tysnes</name><affiliations><json:string>Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, New York, USA</json:string><json:string>Department of Neurology, Haukeland University Hospital, Bergen, Norway</json:string></affiliations></json:item><json:item><name>Jan Petter Larsen</name><affiliations><json:string>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Paul M Thompson</name><affiliations><json:string>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</json:string><json:string>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</json:string></affiliations></json:item><json:item><name>Johanne H Somme</name><affiliations><json:string>Department of Neurology, Cruces University Hospital, Baracaldo, Spain</json:string></affiliations></json:item><json:item><name>Liana G Apostolova</name><affiliations><json:string>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</json:string><json:string>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Movement disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Memory</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's Disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Mri</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Image Analysis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Cognition</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Background and objective Cognitive impairment, including impairment of episodic memory, is frequently found in newly diagnosed Parkinson's disease (PD). In this longitudinal observational study we investigated whether performance in memory encoding, retention, recognition and free recall is associated with reduced hippocampal radial distance. Methods We analysed baseline T1-weighted brain MRI data from 114 PD subjects without cognitive impairment, 29 PD subjects with mild cognitive impairment and 99 normal controls from the ParkWest study. Age- and education-predicted scores for the California Verbal Learning Test 2 (CVLT-2) and tests of executive function were regressed against hippocampal radial distance while adjusting for imaging centre. Results There was no association between encoding or performance on executive tests and hippocampal atrophy in the PD group. In the full PD sample we found bilaterally significant associations between lower delayed free recall scores and hippocampal atrophy in the CA1, CA3 and subiculum area (left, p=0.0013; right, p=0.0082). CVLT-2 short delay free recall scores were associated with bilateral hippocampal CA1 and subicular atrophy in the full PD sample (left, p=0.013; right, p=0.047). CVLT-2 recognition scores showed a significant association with right-sided subicular and CA1 atrophy in the full PD sample (p=0.043). Conclusions At the time of PD diagnosis, subjects’ verbal memory performance in recall and recognition are associated with atrophy of the hippocampus, while encoding is not associated with hippocampal radial distance. We postulate that impaired recall and recognition might reflect deficient memory consolidation at least partly due to structural hippocampal changes.</abstract><qualityIndicators><score>7.928</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1744</abstractCharCount><pdfWordCount>5026</pdfWordCount><pdfCharCount>34199</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>244</abstractWordCount></qualityIndicators><title>Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson's disease</title><pmid><json:string>23154124</json:string></pmid><genre><json:string>research-article</json:string></genre><host><volume>84</volume><pages><first>23</first></pages><issn><json:string>0022-3050</json:string></issn><issue>1</issue><genre></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-330X</json:string></eissn><title>Journal of Neurology, Neurosurgery & Psychiatry</title></host><publicationDate>2013</publicationDate><copyrightDate>2012</copyrightDate><doi><json:string>10.1136/jnnp-2012-303054</json:string></doi><id>0D0083EA1BD08FEC6331BC79186B5DB943BDD70D</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/0D0083EA1BD08FEC6331BC79186B5DB943BDD70D/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/0D0083EA1BD08FEC6331BC79186B5DB943BDD70D/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/0D0083EA1BD08FEC6331BC79186B5DB943BDD70D/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>BMJ Publishing Group Ltd</publisher><availability><p>BMJ</p></availability><date>2012-11-15</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson's disease</title><author><persName><forename type="first">Mona K</forename><surname>Beyer</surname></persName><affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Radiology and Nuclear Medicine–Rikshospitalet, Oslo University Hospital, Oslo, Norway</affiliation></author><author><persName><forename type="first">Kolbjorn S</forename><surname>Bronnick</surname></persName><affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Kristy S</forename><surname>Hwang</surname></persName><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</affiliation></author><author><persName><forename type="first">Niels</forename><surname>Bergsland</surname></persName><affiliation>Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, New York, USA</affiliation></author><author><persName><forename type="first">Ole Bjorn</forename><surname>Tysnes</surname></persName><affiliation>Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</affiliation></author><author><persName><forename type="first">Jan Petter</forename><surname>Larsen</surname></persName><affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Paul M</forename><surname>Thompson</surname></persName><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</affiliation></author><author><persName><forename type="first">Johanne H</forename><surname>Somme</surname></persName><affiliation>Department of Neurology, Cruces University Hospital, Baracaldo, Spain</affiliation></author><author><persName><forename type="first">Liana G</forename><surname>Apostolova</surname></persName><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</affiliation></author></analytic><monogr><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="pISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-01"></date><biblScope unit="volume">84</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="23">23</biblScope></imprint></monogr><idno type="istex">0D0083EA1BD08FEC6331BC79186B5DB943BDD70D</idno><idno type="DOI">10.1136/jnnp-2012-303054</idno><idno type="href">jnnp-84-23.pdf</idno><idno type="ArticleID">jnnp-2012-303054</idno><idno type="PMID">23154124</idno><idno type="local">jnnp;84/1/23</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2012-11-15</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Background and objective Cognitive impairment, including impairment of episodic memory, is frequently found in newly diagnosed Parkinson's disease (PD). In this longitudinal observational study we investigated whether performance in memory encoding, retention, recognition and free recall is associated with reduced hippocampal radial distance. Methods We analysed baseline T1-weighted brain MRI data from 114 PD subjects without cognitive impairment, 29 PD subjects with mild cognitive impairment and 99 normal controls from the ParkWest study. Age- and education-predicted scores for the California Verbal Learning Test 2 (CVLT-2) and tests of executive function were regressed against hippocampal radial distance while adjusting for imaging centre. Results There was no association between encoding or performance on executive tests and hippocampal atrophy in the PD group. In the full PD sample we found bilaterally significant associations between lower delayed free recall scores and hippocampal atrophy in the CA1, CA3 and subiculum area (left, p=0.0013; right, p=0.0082). CVLT-2 short delay free recall scores were associated with bilateral hippocampal CA1 and subicular atrophy in the full PD sample (left, p=0.013; right, p=0.047). CVLT-2 recognition scores showed a significant association with right-sided subicular and CA1 atrophy in the full PD sample (p=0.043). Conclusions At the time of PD diagnosis, subjects’ verbal memory performance in recall and recognition are associated with atrophy of the hippocampus, while encoding is not associated with hippocampal radial distance. We postulate that impaired recall and recognition might reflect deficient memory consolidation at least partly due to structural hippocampal changes.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Memory</term></item><item><term>Parkinson's Disease</term></item><item><term>Mri</term></item><item><term>Image Analysis</term></item><item><term>Cognition</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2012-11-15">Created</change><change when="2013-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/0D0083EA1BD08FEC6331BC79186B5DB943BDD70D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">jnnp</journal-id><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-id journal-id-type="publisher-id">jnnp</journal-id><journal-title>Journal of Neurology, Neurosurgery & Psychiatry</journal-title><abbrev-journal-title abbrev-type="publisher">J Neurol Neurosurg Psychiatry</abbrev-journal-title><abbrev-journal-title>J Neurol Neurosurg Psychiatry</abbrev-journal-title><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">jnnp-2012-303054</article-id><article-id pub-id-type="doi">10.1136/jnnp-2012-303054</article-id><article-id pub-id-type="other">jnnp;84/1/23</article-id><article-id pub-id-type="other">jnnp;jnnp-2012-303054</article-id><article-id pub-id-type="pmid">23154124</article-id><article-id pub-id-type="other">23</article-id><article-id pub-id-type="other">jnnp-2012-303054</article-id><article-categories><subj-group subj-group-type="heading"><subject>Movement disorders</subject></subj-group></article-categories><title-group><article-title>Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson's disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Beyer</surname><given-names>Mona K</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Bronnick</surname><given-names>Kolbjorn S</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hwang</surname><given-names>Kristy S</given-names></name><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Bergsland</surname><given-names>Niels</given-names></name><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Tysnes</surname><given-names>Ole Bjorn</given-names></name><xref ref-type="aff" rid="af5">5</xref><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Larsen</surname><given-names>Jan Petter</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Thompson</surname><given-names>Paul M</given-names></name><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Somme</surname><given-names>Johanne H</given-names></name><xref ref-type="aff" rid="af7">7</xref></contrib><contrib contrib-type="author"><name><surname>Apostolova</surname><given-names>Liana G</given-names></name><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af4">4</xref></contrib></contrib-group><aff id="af1"><label>1</label>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</aff><aff id="af2"><label>2</label>Department of Radiology and Nuclear Medicine–Rikshospitalet, Oslo University Hospital, Oslo, Norway</aff><aff id="af3"><label>3</label>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</aff><aff id="af4"><label>4</label>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</aff><aff id="af5"><label>5</label>Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, New York, USA</aff><aff id="af6"><label>6</label>Department of Neurology, Haukeland University Hospital, Bergen, Norway</aff><aff id="af7"><label>7</label>Department of Neurology, Cruces University Hospital, Baracaldo, Spain</aff><author-notes><corresp><label>Correspondence to</label> Dr Mona Kristiansen Beyer, Division for Diagnostics and Intervention–Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, Oslo 02770, Norway; <email>monbey@ous-hf.no</email></corresp></author-notes><pub-date pub-type="ppub"><month>1</month><year>2013</year></pub-date><pub-date pub-type="epub-original"><day>15</day><month>11</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>15</day><month>11</month><year>2012</year></pub-date><volume>84</volume><volume-id pub-id-type="other">84</volume-id><volume-id pub-id-type="other">84</volume-id><issue>1</issue><issue-id pub-id-type="other">jnnp;84/1</issue-id><issue-id pub-id-type="other">1</issue-id><issue-id pub-id-type="other">84/1</issue-id><fpage>23</fpage><history><date date-type="received"><day>1</day><month>5</month><year>2012</year></date><date date-type="rev-recd"><day>25</day><month>8</month><year>2012</year></date><date date-type="accepted"><day>28</day><month>8</month><year>2012</year></date></history><permissions><copyright-statement>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="jnnp-84-23.pdf"></self-uri><abstract><sec><title>Background and objective</title><p>Cognitive impairment, including impairment of episodic memory, is frequently found in newly diagnosed Parkinson's disease (PD). In this longitudinal observational study we investigated whether performance in memory encoding, retention, recognition and free recall is associated with reduced hippocampal radial distance.</p></sec><sec><title>Methods</title><p>We analysed baseline T1-weighted brain MRI data from 114 PD subjects without cognitive impairment, 29 PD subjects with mild cognitive impairment and 99 normal controls from the ParkWest study. Age- and education-predicted scores for the California Verbal Learning Test 2 (CVLT-2) and tests of executive function were regressed against hippocampal radial distance while adjusting for imaging centre.</p></sec><sec><title>Results</title><p>There was no association between encoding or performance on executive tests and hippocampal atrophy in the PD group. In the full PD sample we found bilaterally significant associations between lower delayed free recall scores and hippocampal atrophy in the CA1, CA3 and subiculum area (left, p=0.0013; right, p=0.0082). CVLT-2 short delay free recall scores were associated with bilateral hippocampal CA1 and subicular atrophy in the full PD sample (left, p=0.013; right, p=0.047). CVLT-2 recognition scores showed a significant association with right-sided subicular and CA1 atrophy in the full PD sample (p=0.043).</p></sec><sec><title>Conclusions</title><p>At the time of PD diagnosis, subjects’ verbal memory performance in recall and recognition are associated with atrophy of the hippocampus, while encoding is not associated with hippocampal radial distance. We postulate that impaired recall and recognition might reflect deficient memory consolidation at least partly due to structural hippocampal changes.</p></sec></abstract><kwd-group><kwd>Memory</kwd><kwd>Parkinson's Disease</kwd><kwd>Mri</kwd><kwd>Image Analysis</kwd><kwd>Cognition</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Mona K</namePart><namePart type="family">Beyer</namePart><affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Radiology and Nuclear Medicine–Rikshospitalet, Oslo University Hospital, Oslo, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kolbjorn S</namePart><namePart type="family">Bronnick</namePart><affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kristy S</namePart><namePart type="family">Hwang</namePart><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Niels</namePart><namePart type="family">Bergsland</namePart><affiliation>Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ole Bjorn</namePart><namePart type="family">Tysnes</namePart><affiliation>Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan Petter</namePart><namePart type="family">Larsen</namePart><affiliation>Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul M</namePart><namePart type="family">Thompson</namePart><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Johanne H</namePart><namePart type="family">Somme</namePart><affiliation>Department of Neurology, Cruces University Hospital, Baracaldo, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Liana G</namePart><namePart type="family">Apostolova</namePart><affiliation>Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</affiliation><affiliation>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2013-01</dateIssued><dateCreated encoding="w3cdtf">2012-11-15</dateCreated><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Background and objective Cognitive impairment, including impairment of episodic memory, is frequently found in newly diagnosed Parkinson's disease (PD). In this longitudinal observational study we investigated whether performance in memory encoding, retention, recognition and free recall is associated with reduced hippocampal radial distance. Methods We analysed baseline T1-weighted brain MRI data from 114 PD subjects without cognitive impairment, 29 PD subjects with mild cognitive impairment and 99 normal controls from the ParkWest study. Age- and education-predicted scores for the California Verbal Learning Test 2 (CVLT-2) and tests of executive function were regressed against hippocampal radial distance while adjusting for imaging centre. Results There was no association between encoding or performance on executive tests and hippocampal atrophy in the PD group. In the full PD sample we found bilaterally significant associations between lower delayed free recall scores and hippocampal atrophy in the CA1, CA3 and subiculum area (left, p=0.0013; right, p=0.0082). CVLT-2 short delay free recall scores were associated with bilateral hippocampal CA1 and subicular atrophy in the full PD sample (left, p=0.013; right, p=0.047). CVLT-2 recognition scores showed a significant association with right-sided subicular and CA1 atrophy in the full PD sample (p=0.043). Conclusions At the time of PD diagnosis, subjects’ verbal memory performance in recall and recognition are associated with atrophy of the hippocampus, while encoding is not associated with hippocampal radial distance. We postulate that impaired recall and recognition might reflect deficient memory consolidation at least partly due to structural hippocampal changes.</abstract><subject><genre>Keywords</genre><topic>Memory</topic><topic>Parkinson's Disease</topic><topic>Mri</topic><topic>Image Analysis</topic><topic>Cognition</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neurology, Neurosurgery & Psychiatry</title></titleInfo><titleInfo type="abbreviated"><title>J Neurol Neurosurg Psychiatry</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0022-3050</identifier><identifier type="eISSN">1468-330X</identifier><identifier type="PublisherID">jnnp</identifier><identifier type="PublisherID-hwp">jnnp</identifier><identifier type="PublisherID-nlm-ta">J Neurol Neurosurg Psychiatry</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>84</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>23</start></extent></part></relatedItem><identifier type="istex">0D0083EA1BD08FEC6331BC79186B5DB943BDD70D</identifier><identifier type="DOI">10.1136/jnnp-2012-303054</identifier><identifier type="href">jnnp-84-23.pdf</identifier><identifier type="ArticleID">jnnp-2012-303054</identifier><identifier type="PMID">23154124</identifier><identifier type="local">jnnp;84/1/23</identifier><accessCondition type="use and reproduction" contentType="copyright">Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</accessCondition><recordInfo><recordContentSource>BMJ</recordContentSource></recordInfo></mods></metadata><annexes><json:item><original>true</original><mimetype>image/jpeg</mimetype><extension>jpeg</extension><uri>https://api.istex.fr/document/0D0083EA1BD08FEC6331BC79186B5DB943BDD70D/annexes/jpeg</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002452 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 002452 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:0D0083EA1BD08FEC6331BC79186B5DB943BDD70D
|texte= Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |